Prescription Baclofen Drug Information
GENERIC NAME: baclofen
BRAND NAME: Lioresal, KemstroPREPARATIONS: Tablets: 10 and 20 mg. Intrathecal: 0.05 mg/ml, 10 mg/5ml, 10 mg/20 ml
STORAGE: Baclofen should be stored between 15°C (59°F) and 30°C (86°F).
PRESCRIBED FOR: Baclofen is used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain due to multiple sclerosis.
DOSING: The usual starting dose of baclofen for adults is 5 mg given three times daily. Based on the response, the dose can be increased gradually every three days to a maximum of 80 mg/day in several doses.
DRUG INTERACTIONS: Use of baclofen with other drugs that also depress the function of nerves may lead to additional reduction in brain function.
In addition to the risk of depressing brain function, the use of baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together may cause muscle weakness.
Because baclofen can increase blood sugar, doses of antidiabetic drugs may need to be adjusted when baclofen is begun.
PREGNANCY: The use of baclofen by pregnant women has not been evaluated.
NURSING MOTHERS: Baclofen can be detected in the breast milk of mothers taking oral baclofen. No information is available on the presence of baclofen in the breast milk of mothers receiving baclofen intrathecally.
SIDE EFFECTS: Baclofen may cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.
Abrupt discontinuation of oral baclofen may cause seizures and hallucinations. Abrupt discontinuation of intrathecal baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown) that can progress to failure of several organs, including the kidney, and even death.
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